MyBioSource.com's NPC1L1 Antibody (N-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The NPC1L1 Antibody (N-term) was generated using NPC1 like 1, and NPC1L1 as the antigen and it reacts with Human.
Description
The protein encoded by this gene is a multi-pass membrane
protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1)
domain and a putative sterol-sensing domain (SSD) which includes a
YQRL motif functioning as a plasma membrane to trans-Golgi network
transport signal in other proteins. This protein takes up free
cholesterol into cells through vesicular endocytosis and plays a
critical role in the absorption of intestinal cholesterol. It also
has the ability to transport alpha-tocopherol (vitamin E). The drug
ezetimibe targets this protein and inhibits the absorption of
intestinal cholesterol and alpha-tocopherol. In addition, this
protein may play a critical role in regulating lipid metabolism.
Polymorphic variations in this gene are associated with plasma
total cholesterol and low-density lipoprotein cholesterol (LDL-C)
levels and coronary heart disease (CHD) risk. Alternatively spliced
transcript variants encoding different isoforms have been found for
this gene